NY-ESO-1 is known as a cancer/testis antigen and widely expressed in 10% to 50% of various tumors of different origins including prostate, breast, lung, melanoma, thyroid, squamous head and neck, as well as 70% to 80% of synovial cell sarcomas. Moreover, NY-ESO-1 expression is only restricted in adult testis and absent in normal somatic cells. Recent studies demonstrate that highly expressed NY-ESO-1 is mostly found in patients with relapsing multiple myeloma (MM) or cytogenetic abnormality. Learn more: anti-NY-ESO-1 CAR-T in vivo assay